These two surprisingly have more similarities, such as starting price and ground shadow size, than difference, like body structure, horsepower, and maximum occupancy. First of all, these two have similarly-sized dimensions, even though one is a Pickup and the other a Van. Also, the 2016 F-350 Super Duty SuperCab has a more powerful engine than the 2016 Sprinter. And finally, there is a difference in the number of passengers; the Sprinter seats two more the F-350 Super Duty SuperCab. Among similarities are the starting price and ground shadow size.